Alendronate is a bone resorption inhibiting bisphosphonate. The most common brand name is Fosamax. There is a dosage form specific Binosto which is a tablet that dissolves in a solution. The main indication is in the treatment of osteoporosis. Some considerations to make for patients is the supplementation of Ca and Vitamin-D if there is inadequate dietary intake. When taking the tablet it should be administered with water and taken 30 minutes before the first meal or medication of the day. It’s also very important to avoid lying down for 30 minutes after taking it. The common dosing is 70 mg PO qd. There is an alternative dosing for osteoporosis which is 5-10 mg po qd. The most common side effects are heartburn, upset stomach and nausea. When monitoring patients the bone mineral density (BMD) should be taken at baseline and periodically thereafter.



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